76M T1bN2(paratracheal Ln)M0-StageIIIA adeno-Ros+ve
PDL1-0
PFT fine
neoadjuvant chemo+ I/O or surgery upfront
Maj of studies didnt report ROS but i worry about ? benefit + toxicity
Oncology Brothers Sandip Patel MD H. Jack West, MD Rami Manochakian MD, FASCO 🇺🇸🇸🇾CancerEducation Devika Das, MD, MSHQS Patrick Forde Santhosh Ambika

Bijoy Telivala Oncology Brothers Sandip Patel MD H. Jack West, MD Rami Manochakian MD, FASCO 🇺🇸🇸🇾CancerEducation Devika Das, MD, MSHQS Patrick Forde Santhosh Ambika Interesting case. I usually don't offer IO to patients with resectable tumors bearing an AGA in ROS1 or NTRK. They respond poorly to IO and it may compromise your opportunity to give TKI at PD. I prefer to give them neoadjuvant chemo followed by surgery, and close follow-up.