Psychoanalysis is routinely dismissed because it is unscientific. Clinical psychologist and writer Frank Tallis argues that developments in evolutionary psychology and more recently neuroscience require a more balanced assessment of Freud’s legacy. tinyurl.com/yyhxvs9n

Chu et al. identify specific atrophy networks associated with different clinical subtypes of frontotemporal dementia, and with apathy and disinhibition, and propose that the findings will aid the selection of future neuromodulation targets. tinyurl.com/p8873wk7

Neuroinflammation is a player in coma, but in which role?

New scientific commentary by Olli Tenovuo & David J Loane tinyurl.com/ftswa9u8

Babu et al. evaluate the safety, pharmacokinetics, and pharmacodynamic activity of apilimod dimesylate in C9orf72 ALS in a randomized, biomarker-endpoint phase 2a trial. tinyurl.com/3sr799dk

Yao et al. identify Tiam1-mediated maladaptive plasticity in the spinal nociceptive network as a cause of the development and maintenance of morphine tolerance and hyperalgesia. Inhibiting Tiam1 signalling reduced morphine tolerance. tinyurl.com/56436ejp

Functional implication for myelin regeneration in recovery from ischaemic stroke

New scientific commentary by Stavros Vagionitis & Ragnhildur Thóra Káradóttir tinyurl.com/47yc97sd

Record et al. present the genetic breakdown for 1515 patients with Charcot-Marie-Tooth disease assessed at a single specialist inherited neuropathy centre, where whole genome sequencing contributed to a ‘solved’ rate of 76.9%. tinyurl.com/ztpnb2fn

Cholinergic and noradrenergic aspects of Parkinson’s disease

New Editorial in this month's Brain: tinyurl.com/3r77nw7b

Herbet et al. examine how machine learning algorithms can be used to predict cognitive outcomes following glioma resection. They argue that three factors should be used as predictors: resection topography, structure-function phenotype, and neuroplasticity. tinyurl.com/2s4abfbh

Macdonald-Laurs et al. describe the clinical, imaging, histopathological and genetic features of 85 patients with focal epilepsy and bottom-of-sulcus dysplasia. tinyurl.com/bdh2x3he

Di Berardino et al. show that induction of Scn1a haploinsufficiency in mice at P2, P30 or P60 elicits a classic Dravet syndrome phenotype. Maintenance of physiological levels of Nav1.1 during brain devpt is thus not sufficient to prevent Dravet symptoms. tinyurl.com/2etkz6v3

Serrano del Pueblo et al. report that patients with long COVID have cognitive difficulties vs controls who recovered completely from SARS-CoV-2. The cognitive deficits are associated with altered brain connectivity, particularly of white matter regions. tinyurl.com/pbsyuze9

Cortical remyelination in multiple sclerosis: a target for disease monitoring and intervention

New scientific commentary by Caterina Mainero, Alessandro Miscioscia & Constantina Treaba tinyurl.com/2yh3zp6h

Two book reviews in this month's Brain: Masud Husain reviews Charan Ranganath's 'Why we remember' tinyurl.com/358hwfnx and Stephen Fleming reviews Andy Clark's 'The Experience Machine' tinyurl.com/mt2kd67u

Tanaka et al. investigate whether tau pathology is present in the cranial and spinal nerves of individuals with tauopathies, and find that prominent peripheral nervous system tau distinguishes progressive supranuclear palsy from other tau-based disorders. tinyurl.com/27w7djh8

Learning the value of experience

New scientific commentary by Campbell Le Heron & Trevor TJ Chong tinyurl.com/y9r843v7

Welcome to the 17th episode of The Brain Podcast - This episode features a discussion with Dr Bénédicte Ballanger.

Do noradrenergic alterations in Parkinson’s disease indicate a therapeutic target? A combined PET & neuromelanin MRI study

Access here:
sites.libsyn.com/424160/do-nora…

New issue of Brain now online! academic.oup.com/brain/issue/14…

Nilsson et al. explore potential synaptic CSF biomarkers of cognitive decline in Alzheimer's disease and other dementia disorders, and find that the ratios of specific proteins can be used to predict cognitive decline and brain atrophy. tinyurl.com/2hr4mm79

Alhassen et al. show that L-DOPA elicits a delayed motor response in a mouse model of PD, even when its conversion to DA is blocked. The motor response is accompanied by a surge in brain ophthalmate, suggesting that ophthalmate may modulate motor function. tinyurl.com/4p8wwenn