RAC2 mutations define phenotype: constitutively active, RAS-like cause SCID, dominant-negative resembleLAD, dominant-activating cause CID. ow.ly/TSMk50ReqxP #clinicaltrialsandobservations #immunobiologyandimmunotherapy #phagocytesgranulocytesandmyelopoiesis

Targeting bacteria, their toxins, and downstream signaling pathways in malignant T cells abrogate the induction of drug resistance. ow.ly/xrt850ReqcE #lymphoidneoplasia #immunobiologyandimmunotherapy

PEAR1 and CBL variants demonstrate time-specific genetic influences on platelet count throughout the course of pregnancy. ow.ly/VRQV50RepJ4 #plateletsandthrombopoiesis #thrombocytopenia

Thymoma with aberrant expression of CD20: a potential diagnostic pitfall of B-cell lymphoma
ow.ly/5LgJ50RejlV #bloodwork #lymphoidneoplasia

T-cell dysfunctions in myelodysplastic syndromes ow.ly/OTSC50R8Keb #hematopoiesisandstemcells #immunobiologyandimmunotherapy #myeloidneoplasia

An evolving understanding of low VWF and type 1 VWD ow.ly/joxs50R8JQb #thrombosisandhemostasis

Uncovering new layers of Ph+ ALL biology ow.ly/flka50R8JkZ #lymphoidneoplasia

A way to “mimic” the pathophysiology of acquired SAA
ow.ly/bfVf50R8IMB #hematopoiesisandstemcells

Subcutaneous emicizumab administered from birth has the potential to reduce the risk of ICH and joint bleeds before damage occurs. ow.ly/eYnO50R8K4s #clinicaltrialsandobservations #pediatrichematology #thrombosisandhemostasis

Whole-genome CRISPR screening identified STAT3 or neddylation genes as positive or negative regulators of PD-L1 expression in ATLL cells. ow.ly/bC3j50R8JLm #lymphoidneoplasia #immunobiologyandimmunotherapy

SETBP1 mutations discriminate between 2 subtypes of triple-negative myelofibrosis, with different genetic landscape and aggressiveness. ow.ly/LFw050R8Jes #myeloidneoplasia #hematopoiesisandstemcells

Hydroxyurea reduces infections in children with sickle cell anemia in Uganda ow.ly/oOBq50R8IH1 #clinicaltrialsandobservations #pediatrichematology #redcellsironanderythropoiesis #sicklecelldisease #SCD

Glad tidings and joy for children with SCA ow.ly/Puvk50R8K19 #clinicaltrialsandobservations

SETBP1 sets the stage ow.ly/LoJC50R8JGp #myeloidneoplasia

Targeting PD-L1 to treat ATLL?
ow.ly/pFtV50R8J51 #lymphoidneoplasia

A treatment bridge for infants with hemophilia
ow.ly/5Rre50R8IC3 #clinicaltrialsandobservations

How I reduce and treat posttransplant relapse of MDS ow.ly/OtZb50R8Kgp #howitreat #myeloidneoplasia #transplantation

Antigens associated with persistent viral infections can mimic epitopes presented on hematopoietic progenitor cells. ow.ly/TZyO50R8JU8 #hematopoiesisandstemcells #immunobiologyandimmunotherapy

“Multilineage” vs “lymphoid-only” BCR::ABL1 involvement and distinct cooperating events determine gene expression in BCR::ABL1-positive ALL. ow.ly/3fLu50R8JAT #lymphoidneoplasia #clinicaltrialsandobservations