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I would like to share the story of how a patient with cancer came up with the idea for a randomized trial, & how listening to him saved a lot of lives. 1/ In 2002, I had just completed a randomized trial with the notorious drug thalidomide for the cancer, multiple myeloma.

Our new JAMA Cardiology study finds that many US adults don't know that they have hypertension, diabetes, or high cholesterol Nearly 1 in 3 young adults w/ hypertension, 2 in 5 with diabetes, and 1 in 4 with high cholesterol are unaware of their condition. bit.ly/45an6MC

This is an amazing, concise review on weight management for cardiovascular disease. Congrats to everyone involved! Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 Michelle Kittleson MD PhD Rishi Rikhi, MD🌱MS Beverly G. Tchang, MD JACC Journals jacc.org/doi/10.1016/j.…

Today's big biotech win is that we might be on the verge of a cure for type-1 diabetes🧵 Twelve diabetics were injected with stem cell-derived pancreatic islets. They started producing insulin again. One year in, 10/12 participants no longer needed to inject insulin.

You know a professionally mature intellectual space when you experience it. A room full of people where it’s okay to disagree, it’s okay to say I don’t know enough, it’s okay to ask a question that seems trivial - and yet feel valued, respected and appreciated. You leave

🏆 In the past month, we have added 2 feathers to our cap: 🌍Ranked 22nd Best Medical School in the World 🇮🇳 Ranked Best Medical College in India IndiaToday Proud to keep raising the bar for medical education and healthcare! bestcolleges.indiatoday.in/news-detail/me… ceoworld.biz/2025/04/06/bes…

Tirzepatide and semaglutide are both highly effective for the management of obesity. How the two drugs compare in patients with obesity but without diabetes has been unknown. Research findings from the SURMOUNT-5 phase 3b trial are summarized in a short video.

🚨 The CarDS Lab at Yale is recruiting postdocs in our clinician–data scientist track! 🔹 MD or MD/PhD 🔹 Python/R skills 🔹 Research experience 🔹 Passion for AI + digital health 📝 Apply early: CV + 250-word statement 🔗 apply.cards-lab.org/apply/CATSP004 #AI #Cardiology #Postdoc

One of my favorite papers in recent years included this diagram. It shows the impact of controlling for three different types of variables: confounders, colliders, and mediators. With confounders, control is good. With the others, you ruin your result by controlling.

🫀 ECGs power many #AI applications, but not everyone gets an ECG. 📱 Our single-lead, noise-resilient AI-ECG detects structural heart disease & predicts heart failure risk using ECGs from wearable/portable devices 🔗 academic.oup.com/ehjdh/article/… Yale School of Medicine Yale Cardiology rohan khera

Presented at #ESCCongress: In patients with cardiovascular disease and an implantable cardioverter–defibrillator, increasing potassium levels to the high-normal range reduced the risk of arrhythmia events, hospitalizations, and death. Full POTCAST trial results:

From JAMA: Patch-based remote ECG screening for atrial fibrillation in older individuals with moderate to high risk of stroke modestly increased diagnosis and anticoagulation but had limited effect on #stroke rates. #ESCCongress #WCCardio ja.ma/47Sbqzj

Program Director's Note - My Immigrant Family A #ProgramDirectorsNote to my Yale IM Traditional Residency Program residents. You don’t have to look far to see how immigrants contribute to medical science, education, and clinical care. At Yale Internal Medicine and throughout America. open.substack.com/pub/siegelmark…

📢We are pleased to announce publication of the EASO Algorithm for the pharmacological treatment of obesity and its complications in Nature Medicine. Obesity is an adiposity-based chronic disease (ABCD); assess severity and complications to guide treatment doi.org/10.1038/s41591…

🔥 New in Nature Medicine How do you communicate lifetime benefits expected with HFpEF therapies? New data from 3 RCTs (#DELIVER #FINEARTS #PARAGON) estimate up to *5 years* of event-free survival w combination Rx #GDMT for HFpEF has finally arrived! 🔗nature.com/articles/s4159…

✅✅ A reminder by Dr. Rahaf Ajaj: She wasn’t on the Stanford list… but she made it to the Nobel stage. 🏅 Mary E. Brunkow, one of this year’s Nobel Prize winners in Medicine, has only 34 published papers and an H-index of 21. She never appeared in Stanford’s ranking of the

#Halloween2025 Really scary.

First time at #AHA25 in New Orleans - learning about coffee preventing A-Fib while being continuously caffeinated. Learned so much and caught up with so many friends in Cardiology! 🫀

Loved this reflection on a simple question that now carries layers of meaning in our changing world. #MedTwitter jamanetwork.com/journals/jama/…

Science - you beauty