Big day today for patients with elevated Triglycerides with reduction in apo C-III, TG and pancreatitis. And a double whammy for our group and Ionis. 2 important trials presented and 2 back-to-back NEJM papers!. Big thanks to Brian Bergmark and Erik Stroes. Can it get…

Elevated plasma triglycerides are associated with increased risk of later psoriasis in both observational and causal, genetic analyses. Novel discovery in 100,000 individuals from the Copenhagen General Population Study
academic.oup.com/bjd/advance-ar…
academic.oup.com/bjd/advance-ar…

Risk of peripheral artery disease conferred by elevated apoB-containing lipoproteins was explained mainly by elevated remnants, while risk of myocardial infarction was explained by both elevated remnants and LDL.

ahajournals.org/doi/10.1161/AT…

Please help us nominate enthusiastic and engaged members of EAS who are interested in taking a more active role in EAS activities as
Vice President, Secretary, Treasurer, 3 Ordinary Members
Nomination forms for the Executive Committee Election 2024 – EAS eas-society.org

Fantastic choice - congratulations to Bart - looking forward to hearing your lecture in Lyon.

🤔Do Triglyceride‐Rich Lipoproteins (TRL) Equal Low‐Density Lipoproteins (LDL) in Risk of ASCVD?

👉 Current consensus is moving towards recognizing remnant cholesterol and LDL cholesterols as equals per 1 mmol/L (39 mg/dL) higher levels in the risk assessment of ASCVD; hence,…

The interest in elevated remnant cholesterol as a direct cause of atherosclerotic cardiovascular disease had a slow start; however, interest has increased enourmously recently among scientists and pharma companies. The term was first used in 2007 in a JAMA paper.
Stay tuned!

#CVCT 2023 : Let's talk about TRIGLYCERIDE RICH LIPOPROTEINS TRIALS with Borge G Nordestgaard, @drRSRosenson, Giacomo Ruotolo and many others on November 30th at The National Press Club, Washington DC ! Registered ? globalcvctforum.com/scientific-pro…
#CardioTwitter #CVCT

Thank you so much for this great honor - to Dan Rader, Katherine Wilemon, Josh Knowles, Gisette Soffer, Keith Ferdinand, and all the rest of the team from the Family Heart Foundation! Greetings from Anne and Borge

Low number of small HDL confer increased hazard of sepsis, sepsis-related death, and sepsis-related critical care admission - genetic analyses did not strongly support this as causal; however, increased IL-6 signalling may explain part of the association
ccforum.biomedcentral.com/articles/10.11…

Guidelines from cardiovascular, lipid, and endocrinological societies globally are consistent in relation to considering hypertriglyceridemia a risk factor for ASCVD, but inconsistency regarding recommendation for plasma triglycerides in acute pancreatitis
academic.oup.com/clinchem/artic…

Mild to moderate hypertriglyceridemia, rather than being a direct cause of acute pancreatitis, is associated indirectly because it is a reliable marker of future severe hypertriglyceridemia.
academic.oup.com/clinchem/artic…

Have you made your choice of individuals deserving acknowledgments? Don't delay, submit your nomination today. To learn more about the Prize and its eligibility criteria, please follow this link: eas.to/Anitschkow2024… Prof Kausik Ray FMedSci

👉TG content increases while cholesterol content decreases in HDL and LDL +IDL fractions following normal meals

☝️…thus indirectly endorse use of non-fasting lipid measurements for risk prediction

🔓Open access

atherosclerosis-journal.com/article/S0021-…

European Atherosclerosis Society
Borge G Nordestgaard
Thomas Dayspring

In diabetes elevated remnant cholesterol is the prominent lipoprotein abnormality - and the one that explains most risk of peripheral artery disease, myocardial infarction, ischemic stroke and any ASCVD in diabetes with 58% on statins
link.springer.com/article/10.100…

Does the PROMINENT trial rule out the importance of elevated remnant cholesterol in people on high-intensity statin therapy: DEFINITELY NOT!
academic.oup.com/eurheartj/arti…

Very interesting to deliver the 2023 Akira Yamamoto named plenary lecture on “Remnant cholesterol' at the 2023 APSAVD congress in Malaysia. Huge interst in elevated remnant cholesterol driving excess ASCVD risk, particularly in Asian-Pacific countries with many obese citizens.

Gibbons like to live dangerously

From plasma triglycerides to triglyceride metabolism: effects on mortality in the Copenhagen General Population Study
academic.oup.com/eurheartj/adva…

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“Low-density lipoprotein cholesterol cannot be too low after a myocardial infarction”