Announcing AlphaFold 3: our state-of-the-art AI model for predicting the structure and interactions of all life’s molecules. 🧬

Here’s how we built it with Isomorphic Labs and what it means for biology. 🧵 dpmd.ai/3URDiNo

Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial blog.google/technology/ai/…

This is the end of the world as we know it, if this is reproducible! The new era of functional modeling has begun. I took a transcription factor with an unknown structure and folded it with its recognition sequence embedded in longer DNA. AlphaFold3 accurately positioned the…

Would you like to use Adative sampling but dont know where to start? Or, do you have THE set of coordinates you think that everyone should use? If either of these are yes, please feel free to browse the open apdative science catalogue. Oxford Nanopore
community.nanoporetech.com/adaptive_sampl…

Many #GenomeBrowsers only show one #genome assembly at a time. NCBI presents a new visualization tool called the #ComparativeGenomeViewer ( #CGV ) that aids in pairwise comparison of whole-genome eukaryotic assembly-assembly alignments #PLOSBiology plos.io/3QYDtUP

Genetic characterization of cucumber genetic resources in the NARO Genebank indicates their multiple dispersal trajectories to the East

biorxiv.org/content/10.110…
#plantscience ♻️

Duplex basecalling for whole-genome assembly | Ryan Wick’s bioinformatics blog rrwick.github.io/2024/05/08/dup…

The emerging role of tandem repeats in complex traits go.nature.com/3QC0X1z #Comment by Michael Lamkin & Melissa Gymrek UC San Diego UCSD CSE

Genes commonly express multiple #RNA isoforms. But how to visualise each isoform, how they differ in exonic structure and protein domains, as well as their expression levels from your RNA-seq data?

Excited to introduce IsoVis isomix.org/isovis/ doi.org/10.1093/nar/gk… 1/n

#CRISPR #GenomeEditing techniques can be used to advance melon breeding, highlights recent review from University of Tsukuba.
For example, traits for disease resistance and improved shelf life have been successfully introduced. 🍈🌱
ow.ly/NISe50Ryrao

On The Expanding Versatility of Single Molecule Sequencing for Detecting Anomalous DNA

omicsomics.blogspot.com/2024/05/on-exp…

A cluster of putative resistance genes is associated with a dominant resistance to sunflower broomrape
rdcu.be/dEXzm

🌸 Unlocking the genetic secrets of carnations: 'Baltico' variety genome assembly reveals haplotype-resolved gap-free structure. 🧬 #CarnationGenomics Oxford Journals
Details:doi.org/10.1093/hr/uha…

Fortifying nematode resistance through susceptibility gene inactivation dlvr.it/T6FGFB

Normalizing Lint with the chromosome length L and the average crossover count N predicts a surprisingly similar behavior across various organisms and mutants. We think this hints at common mechanism that governs crossover interference in these cases.

Omics! Omics!: A Peek At QuantumSI's Protein Sequencer omicsomics.blogspot.com/2024/04/a-peek…

Pangenome analysis reveals transposon-driven genome evolution in cotton. #CottonPangenome #TransposableElements BMC Biology
bmcbiol.biomedcentral.com/articles/10.11…

Garlic's genetic traits studied in 606 accessions from 43 countries reveal insights for genetic improvement. 🧬🌱 #GarlicGenetics #CropImprovement Oxford Journals
Details:doi.org/10.1093/hr/uha…

Happy to present banana 🍌 pangenome using Oxford Nanopore duplex data at #nanoporeconf The insights obtained help in breeding new varieties that are resistant to Fusarium Tropical Race 4 (TR4) and Black Sigatoka. Thanks Willem van Rengs for the assemblies and comparisons.

LiftOn is really nice new tool just released by Kuan-Hao Chao, a worthy successor to Alaina Shumate, PhD's Liftoff system. He's speaking about this at RECOMBseq in Boston; see his thread below for more on how to download and what it does