⭐ Highlights from this week in ACR journals:

🔸 A PD-1(high)CD4+ T Cell Population Associated With SSc-ILD
🔸 Risk of GI Perforation With JAKi vs Adalimumab
🔸 Implementation Strategies to Improve Knee OA Care
🔸 Pegloticase and Concomitant Immunomodulatory Therapy

Rheum Research in Brief

Risk of Coccidioidomycosis Infection Among Individuals Using Biologic Response Modifiers, Corticosteroids, and Oral Small Molecules

In ACROR
loom.ly/P5T_6ME

Coccidioidomycosis rates (per 10,000) among Medicare beneficiaries from 2011 to 2016

AC&R special collections provide convenient access to groups of articles centered on a shared rheum topic

Pediatric Rheumatology: loom.ly/WPFTHi0
Reproductive Issues in Rheumatology: loom.ly/QK1mtCw
Rheumatology Training and Work Force: loom.ly/LHtIFZw

Rheum Research in Brief

Utilization of Biologic Disease-Modifying Antirheumatic Therapy in Patients With Rheumatoid Arthritis and Recently Diagnosed Breast Cancer

In AC&R
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Figure: RA medications before and after breast cancer diagnosis

Pts w/ gout using concomitant immunomodulatory drugs while receiving pegloticase infusions were less likely to discontinue pegloticase
Lab abnormalities were uncommon (<5%) among pegloticase users and not higher w/ concomitant immunomodulatory use

In AC&R
loom.ly/1sW6kMc

Rheum Research in Brief

Modulation of IL-23 Signaling With Guselkumab in Biologic-Naive Patients Versus TNF Inhibitor–Inadequate Responders With Active Psoriatic Arthritis

In A&R
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Figure: Mean serum levels over time

Survey data were analyzed to determine characteristics of pts w/ psoriatic arthritis currently prescribed ixekizumab

Results showed ixekizumab was efficacious in treating PsA in real-world clinical practice, complementing efficacy data from RCTs

In ACROR
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Sys. review describes use of implementation strategies in knee OA care management

Using an active learning strategy w/ a patient partner, restructuring funding models, and integrating taxonomies to tailor strategies had most impact

In AC&R
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Michelle M Ramirez, PT, DPT, OCS

Rheum Research in Brief

Inflammatory Arthritis in Systemic Sclerosis: Its Epidemiology, Associations, and Morbidity

In AC&R
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Table: Determinants of inflammatory arthritis in multivariable logistic regression

In a nationwide cohort study of 39,758 patients with rheumatic diseases, researchers showed that rates of gastrointestinal perforation for those initiating a JAKi and adalimumab did not differ

In A&R
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E̺͆p̺͆i̺͆D̺͆e̺͆r̺͆m̺͆E̺͆ FHU TRUE: InnovaTive theRapy for immUne disordErs Hoisnard Lea

🎦 loom.ly/MIchIZQ

Investigation of Tph & Tfh phenotypes in SSc identified a unique CD4 T cell subset, a specific PD-1(high) subpop. that expresses HLA–DR but lacks ICOS, that was expanded in SSc peripheral blood and assoc. with int. lung dis. presence and severity

In ACROR
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Rheum Research in Brief

Clinical Characteristics and Outcomes of Polyarteritis Nodosa

In A&R
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Figures: Evaluation of the first relapse (1) and mortality and survival analysis (2) in patients with PAN.

Sys. review findings highlight importance of measuring adverse social determinants of health in LN to fully understand heterogeneity in LN outcomes and guide future interventions to promote health equity and advance health of all patients with LN

In AC&R
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Patient-reported outcomes in ANCA-associated vasculitis: are the answers in front of our noses?

Editorial on the below study now online in AC&R
loom.ly/9CR9WXM

Among 74 pediatric patients with LN, neither more extrarenal domains at diagnosis nor higher summary score on the 2019 EULAR/ACR criteria for SLE were associated with renal response at 1 year

In ACROR
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Rheum Research in Brief

Predictors of Organ Damage in Systemic Lupus Erythematosus in the Asia Pacific Region

In AC&R
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Figure: Factors associated with organ damage in multivariable analyses.

Rheum Research in Brief

Superiority of Low-Dose Benzbromarone Add-On to Low-Dose Febuxostat Compared With Febuxostat Monotherapy in Gout With Combined-Type Hyperuricemia

In AC&R
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Figure: The trial's primary endpoints

Rheum Research in Brief

Use and Utility of Patient After-Visit Instructions at a University Rheumatology Outpatient Clinic: Status and Randomized Prospective Pilot Intervention Study

In ACROR
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Clinical Image: Burton’s line and scar hyperpigmentation in a patient with severe lead poisoning and saturnine gout

A 35-year-old man with a 3-year history of gout, presented with a 2-month history of abdominal pain and altered mental status

In A&R
loom.ly/3jEjKeI